Control of the hyperpolarization-activated cation current by external anions in rabbit sino-atrial node cells.
نویسندگان
چکیده
منابع مشابه
Inhibition by genistein of the hyperpolarization-activated cation current in porcine sino-atrial node cells.
1 The hyperpolarization-activated cation current (If) was recorded in single pacemaker cells of the porcine sino-atrial node, and the effects of genistein, an isoflavone inhibitor of tyrosine-specific protein kinases was investigated by the whole-cell patch clamp technique. 2 Genistein (20-500 microM) decreased If in a dose-dependent manner with an IC50 value of 62.3 microM and a maximum inhibi...
متن کاملHyperpolarization-Activated Current, If, in Mathematical Models of Rabbit Sinoatrial Node Pacemaker Cells
A typical feature of sinoatrial (SA) node pacemaker cells is the presence of an ionic current that activates upon hyperpolarization. The role of this hyperpolarization-activated current, If, which is also known as the "funny current" or "pacemaker current," in the spontaneous pacemaker activity of SA nodal cells remains a matter of intense debate. Whereas some conclude that If plays a fundament...
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"Funny" (f-) channels have a key role in generation of spontaneous activity of pacemaker cells and mediate autonomic control of cardiac rate; f-channels and the related neuronal h-channels are composed of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel subunits. We have investigated the block of f-channels of rabbit cardiac sino-atrial node cells by ivabradine, a novel heart ...
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15 صفحه اولFacilitation of the L-type calcium current in rabbit sino-atrial cells: effect on cardiac automaticity.
OBJECTIVE The L-type Ca(2+) current (I(Ca,L)) contributes to the generation and modulation of the pacemaker action potential (AP). We investigated facilitation of I(Ca,L) in sino-atrial cells. METHODS Facilitation was studied in regularly-beating cells isolated enzymatically from young albino rabbits (0.8-1 kg). We used the whole-cell patch-clamp technique to vary the frequency of the test de...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1992
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1992.sp019230